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Migar Examples of Carrier-linked Bipartate Prodrugs 5. Enzymes — not just your run of the mill protein! Prodrug readily transported to the site of action Prodrug is rapidly absorbed at the site Selective and rapid conversion to the active drug Kidney and Liver are easy targets due to high perfusion and high metabolic rates Other tissue sites can be problematic for the same reasons Drug migrate slowly site of action to a site of excretion Ideal situation is VERY complex to achieve Example: Azo reduction prontosil sulfanilamide b.
Bioprecursor prodrugs: molecular modification of the active principle. N-Oxidation pralidoxime acetylcholine esterase activator e. About project SlidePlayer Terms of Service.
Sum total of ALL chemical reactions in a living organism Metabolism is about the energy balance in cells, production. Why have such bioprecurrsor if they are not utilised for the purpose of increasing the rate of transportation across the cell membrane? Prodrugs to encourage patient acceptance clindamycin antibacterial.
To make this website work, we log user data and share it with processors. We think you have liked this presentation. Published by Aubrey Johnston Modified over 3 years ago. The lecturer also mentioned that the drugs could sometimes be serendipitously be discovered in their precursor form from a natural source, which makes it cheaper to produce them by harvesting from the source and be used just like that. Read This Before Posting. Awesome, that makes a lot of sense.
What the body does to the drug? Methenamine the lower the pH, the faster the rate of formaldehyde formed blood pH 7. Enter the body by crossing barriers Distributed by the blood to the site of action Biotransform. Share buttons are a little bit lower.
OK Is the passage of drug from its site of administration to its site of action through cell membranes. This may be helpful for increasing prodrkgs, or also if the drug itself is nonspecific in its action. If you wish to download it, please recommend it to your friends in any social system. Auth with social network: Removing substances prpdrugs the body Some substances are very difficult to eliminate — heavy metals such as lead and mercury The body very efficient. Epinephrine anti-glaucoma dipivefrin esterase.
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BIOPRECURSOR PRODRUG PDF